Publications
| 355. |
Ohno, S.; Goodner, R. M.;Confair, D. N.; Mercado, B. Q.; Ellman, J. A. Visible Light Promoted Alkenyl C–H Bond Addition to Dienes and Aldehydes for the Synthesis of Frameworks Relevant to Polyketide Natural Products ACS Catal. 2025, 15, ASAP. |
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| 354. |
Patel, S.; Finnigan, J. D.; Lim, J.; Greenwood, N. S;; Ellman, J. A. Biocatalytic Enantioselective Oxidation of N-Acyl-S-Methyl Sulfenamides for the Asymmetric Synthesis of S-Methyl Sulfoximines Org. Lett. 2025, 27, ASAP. |
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| 353. |
Patel, S.; Cerny, N. P.; Zimmer, L. G.; Chen, S.; Ellman, J. A. Studies on the Mechanism of Styrene Elimination from Sulfilimines: Hammett and Kinetic Isotope Effect Analysis and Computation J. Org. Chem. 2025, 90, 11597–11604. |
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| 352. |
Vigneron, S. F.; Ohno, S.; Braz, J.; Kim, J. Y.; Kweon, O. S.; Webb, C.; Billesbølle, C. B.; Srinivasan, K.; Bhardwaj, K.; Irwin, J. J.; Manglik, A.; Basbaum, A. I.; Ellman, J. A.; Shoichet, B. K. Docking 14 Million Virtual Isoquinuclidines against the μ and κ Opioid Receptors Reveals Dual Antagonists–Inverse Agonists with Reduced Withdrawal Effects ACS Cent. Sci. 2025, 11, 770–790. |
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| 351. |
Boyer, Z. W.; Kwon, N. Y.; Ellman, J. A. Ruthenium-Catalyzed Enantioselective Alkylation of Sulfenamides: A General Approach for the Synthesis of Drug Relevant S-Methyl and S-Cyclopropyl Sulfoximines J. Am. Chem. Soc. 2025, 147, 14954–14959 [write up in Org. Process Res. Dev.: https://pubs.acs.org/doi/10.1021/acs.oprd.5c00249]. |
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| 350. |
Greenwood, N. S.; Boyer, Z. W.; Ellman, J. A.; Gnamm, C. Sulfilimines from a Medicinal Chemist’s Perspective: Physicochemical and in Vitro Parameters Relevant for Drug Discovery J. Med. Chem. 2025, 68, 4079–4100 [Feature Article with a Viewpoint by Prof. Arvidsson: https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c00195]. |
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| 349. |
Goodner, R. M.; Brandes, D. S.; Morais, G. N.; Tao, Q.; Tassone, J. P.; Mercado, B. Q.; Chen, S.; Ellman, J. A. C–H Activation and Sequential Addition to Dienes and Imines: Synthesis of Amines with β-Quaternary Centers and Mechanistic Studies on the Complex Interplay Between the Catalyst and Three Reactants ACS Catal. 2024, 14, 18124–18133 [write up in Synfacts, L02725SF]. |
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| 348. |
Yeo, J.; Tassone, J. P.; Ellman, J. A. Synthesis of α-Quaternary Amides via Cp*Co(III)-Catalyzed Sequential C–H Bond Addition to 1,3-Dienes and Isocyanates Org. Lett. 2024, 26, 9769–9774. |
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| 347. |
Molas, J. C.; Poag, E. M.; Ellman, J. A. Synthesis of Monodehydro-Diketopiperazines Enabled by Cp*Rh(III)-Catalyzed Amine-Directed N–H Functionalization Org. Lett. 2024, 26, 8527–8531 [write up in Synfacts, H00925SF]. |
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| 346. |
Moon, M. H.; Vock, I. W.; Streit, A. D.; Connor, L. J.; Senkina, J.; Ellman, J. A.; Simon, M. D. Disulfide Tethering to Map Small Molecule Binding Sites Transcriptome-wide ACS Chem. Biol. 2024, 19, 2081–2086. |
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| 345. |
Champlin, A. T.; Kwon, N. Y.; Ellman, J. A. Enantioselective S-Alkylation of Sulfenamides by Phase-Transfer Catalysis Angew. Chem. Int. Ed. 2024, 63, e202408820. |
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| 344. |
Patel, S.; Greenwood, N. S.; Mercado, B. Q.; Ellman, J. A. Rh(II)-Catalyzed Enantioselective S-Alkylation of Sulfenamides with Acceptor–Acceptor Diazo Compounds Enables the Synthesis of Sulfoximines Displaying Diverse Functionality Org. Lett. 2024, 26, 6295–6300. |
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| 343. |
Chu, D.; Zoll, A. J.; Ellman, J. A. Copper-Catalyzed Three-Component Synthesis of Highly Substituted Morpholines Org. Lett. 2024, 26, 4803–4807. |
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| 342. |
Greenwood, N. S.; Cerny, N. P.; Deziel, A. P.; Ellman, J. A. Synthesis of N-Acylsulfenamides from (Hetero)Aryl Iodides and Boronic Acids by One-Pot Sulfur-Arylation and Dealkylation Angew. Chem. Int. Ed. 2024, 63, e202315701. |
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| 341. |
Vargas-Rivera, M. A.; Liu, A. S.; Ellman, J. A. Visible-Light-Mediated, Diastereoselective Epimerization of Exocyclic Amines Org. Lett. 2023, 25, 9197–9201. |
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| 340. |
Greenwood, N. S.; Ellman, J. A. Sulfur-Arylation of Sulfenamides via Ullmann-Type Coupling with (Hetero)aryl Iodides Org. Lett. 2023, 25, 4759–4764. |
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| 339. |
Champlin, A. T.; Ellman, J. A. Preparation of Sulfilimines by Sulfur-Alkylation of N-Acyl Sulfenamides with Alkyl Halides J. Org. Chem. 2023, 88, 7607–7614. |
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| 338. |
Chu, D.; Ellman, J. A. Stereospecific Synthesis of Unprotected, α,β-Disubstituted Tryptamines and Phenethylamines from 1,2-Disubstituted Alkenes via a One-Pot Reaction Sequence Org. Lett. 2023, 25, 3654–3658. |
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| 337. |
Greenwood, N. S.; Ellman, J. A. Sulfur-Arylation of Sulfenamides via Chan–Lam Coupling with Boronic Acids: Access to High Oxidation State Sulfur Pharmacophores Org. Lett. 2023, 25, 2830–2834. |
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| 336. |
Liu, J. T.; Brandes, D. S.; Greenwood, N. S.; Ellman, J. A. Synthesis of N-Acylsulfenamides from Amides and N-Thiosuccinimides Synthesis 2023, 55, 2353–2360 [Special Issue dedicated to Prof. David A. Evans]. |
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| 335. |
Zoll, A. J.; Molas, J. C.; Mercado, B. Q.; Ellman, J. A. Imine Directed Cp*Rh(III)-Catalyzed N–H Functionalization and Annulation with Amino Amides, Aldehydes, and Diazo Compounds Angew. Chem. Int. Ed. 2023, 62, e202210822. |
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| 334. |
Tassone, J. P.; Yeo, J. Ellman, J. A. Three-component carboformylation: α-quaternary aldehyde synthesis via Co(III)-catalysed sequential C–H bond addition to dienes and acetic formic anhydride Chem. Sci. 2022, 13, 14320–14326. |
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| 333. |
Shen, Z.; Vargas-Rivera, M.; Rigby, E. L.; Chen, S.; Ellman, J. A. Visible Light-Mediated, Highly Stereoselective Epimerization of Morpholines and Piperazines to the More Stable Isomers ACS Catal. 2022, 12, 12860–12868. |
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| 332. |
Kaplan, A.; Confair, D. N.; Kim, K.; Barros Álvarez, X.; Rodriguiz, R. M.; Yang, Y.; Kweon, O. S.; Che, T.; McCorvy, J.; Kamber, D. N.; Phelan, J. P. Martins, L. C.;...Wetsel, W. C.; Irwin, J. J.; Skiniotis, G.; Shoichet, B. K.; Roth, B. L.; Ellman, J. A. Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity Nature 2022, 610, 582–591. |
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| 331. |
Greenwood, N. S.; Champlin, A. T.; Ellman, J. A. Catalytic Enantioselective Sulfur Alkylation of Sulfenamides for the Asymmetric Synthesis of Sulfoximines J. Am. Chem. Soc. 2022, 144, 17808–17814. |
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| 330. |
Gannam, Z. T. K.; Jamali, H.; Kweon, O. S.; Herrington, J.; Papini, C.; Gentzel, E.; Lolis, E.; Bennett, A. M.; Ellman, J. A.; Anderson, K. S. Defining the Structure-Activity Relationship for a Novel Class of Allosteric MKP5 Inhibitors Eur. J. Med. Chem. 2022, 243, 114712. |
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| 329. |
Brandes, D. S.; Ellman, J. A. C–H bond activation and sequential addition to two different coupling partners: a versatile approach to molecular complexity Chem. Soc. Rev. 2022, 51, 6738 - 6756. |
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| 328. |
Kazerouni, A. M.; Brandes, D. S.; Davies, C. C.; Cotter, L. F.; Mayer, J. M.; Chen, S.; Ellman, J. A. Visible Light-Mediated, Highly Diastereoselective Epimerization of Lactams from the Most Accessible to the More Stable Stereoisomer ACS Catal. 2022, 12, 7798–7803. |
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| 327. |
Xu, C.; Tassone, J. P.; Mercado, B. Q.; Ellman, J. A. Stereoselective Synthesis of Allenyl Alcohols by Cobalt(III)-Catalyzed Sequential C−H Bond Addition to 1,3-Enynes and Aldehydes Angew. Chem. Int. Ed. 2022, 61, e202202364 [Hot Paper]. |
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| 326. |
Chu, D.; Ellman, J. A. Three-Component Friedel–Crafts Transformations: Synthesis of Alkyl and Alkenyl Trifluoromethyl Sulfides and Alkenyl Iodides Org. Lett. 2022, 24, 2921–2925. |