Publications

110. Salisbury, C. M.; Maly, D. J.; Ellman, J. A.
Peptide Microarrays for the Determination of Substrate Specificity
J. Am. Chem. Soc.  2002124, 14868-14870.
109. Ellman, J. A.; Owens, T. D.; Tang, T. P.
N-tert-Butanesulfinyl Imines: Versatile Intermediates for the Asymmetric Synthesis of Amines
Acc. Chem. Res.  200235, 984-995.
108. Tang, T. P.; Ellman, J. A.
Asymmetric Synthesis of beta-Amino Acid Derivatives Incorporating a Broad Range of Substitution Patterns by Enolate Additions to tert-Butanesulfinyl Imines
J. Org. Chem.  200267, 7819-7832.
107. Blatt, N. B.; Bednarski, J. J.; Warner, R. E.; Leonetti, F.; Johnson, K. M.; Boitano, A.; Yung, R.; Richardson, B. C.; Johnson, K. J.; Ellman, J. A. Opipari, A. W.; Glick, G. D.
Benzodiazepine-Induced Superoxide Signals B Cell Apoptosis: Mechanistic Insight and Potential Therapeutic Utility
J. Clin. Invest.  2002110, 1123-1132.
106. Tan, K. L.; Bergman, R. G.; Ellman, J. A.
Intermolecular Coupling of Alkenes to Heterocycles via Rhodium-Catalyzed C-H Bond Activation
J. Am. Chem. Soc.  2002124, 13964-13965.
105. Huang, L.; Ellman, J. A.
General Solid-Phase Procedure to Prepare Novel Cyclic Ketone Inhibitors of the Cysteine Protease Cruzain
Bioorg. Med. Chem. Lett.  200212, 2993-2996.
104. Choi, C. Y. H.; Schneider, E. L.; Kim, J. M.; Gluzman, I. Y.; Goldberg, D. E.; Ellman, J. A.; Marletta, A.
Interference with Heme Binding to Histidine-Rich Protein-2 As an Antimalarial Strategy
Chem. Biol.  20029, 881-889.
103. Chino, M.; Wakao, M.; Ellman, J. A.
Efficient Method to Prepare Hydroxyethylamine-Based Aspartyl Protease Inhibitors with Diverse P1 Side Chains
Tetrahedron  200258, 6305-6310.
102. Brinner, K. M.; Kim, J. M.; Habashita, H.; Gluzman, I. Y.; Goldberg, D. E.; Ellman, J. A.
Novel and Potent Anti-Malarial Agents
Bioorg. Med. Chem.  200210, 3649-3661.
101. Kochi, T.; Tang, T. P.; Ellman, J. A.
Asymmetric Synthesis of syn- and anti-1,3-Amino Alcohols
J. Am. Chem. Soc.  2002124, 6518-6519.
100. Wang, X.; Choe, Y.; Craik, C. S.; Ellman, J. A.
Design and Synthesis of Novel Inhibitors of Gelatinase B
Bioorg. Med. Chem. Lett.  200212, 2201-2204.
99. Tan, K. L.; Bergman, R. G.; Ellman, J. A.
Intermediacy of an N-Heterocyclic Carbene in the Catalytic C-H Activation of Benzimidazole
J. Am. Chem. Soc.  2002124, 3202-3203.
98. Kehoe, J. W.; Maly, D. J.; Verdugo, D. E.; Armstrong, J. I.; Cook, B. N.; Ouyang, Y.-B.; Moore, K. L.; Ellman, J. A.; Bertozzi, C. R.
Tyrosylprotein Sulfotransferase Inhibitors Generated by Combinatorial Target-Guided ligand Assembly
Bioorg. Med. Chem. Lett  200212, 329-332.
97. Maly, D. J.; Leonetti, F.; Backes, B. J.; Dauber, D. S.; Harris, J. L.; Craik, C. S.; Ellman, J. A.
Expedient Solid-Phase Synthesis of Fluorogenic Protease Substrates Using the 7-Amino-4-Carbamoylmethylcoumarin (ACC) Fluorophore
J. Org. Chem.  200267, 910-915.
96. Maly, D. J.; Huang, L.; Ellman, J. A.
Combinatorial Strategies for Targeting Protein Families.  Application to the Proteases
ChemBioChem  20023, 16-37.
95. Huang, L.; Lee, A.; Ellman, J. A.
Identification of Potent and Selective Mechanism-Based Inhibitors of the Cysteine Protease Cruzain Using Solid-Phase Parallel Synthesis
J. Med. Chem.  200245, 676-684.
94. Dauber, D. S.; Ziermann, R. Parkin, N.; Maly, D. J.; Mahrus, S.; Harris, J. L.; Ellman, J. A.; Petropoulos, C.; Craik, C. S.
Altered Substrate Specificity of Drug-Resistant Human Immunodeficiency Virus Type 1 Protease
J. Virol.  200276, 1359-1368.
93. Lee. A.; Ellman, J. A.
Parallel Solution-Phase Synthesis of Mechanism-Based Cysteine Protease Inhibitors
Org. Lett.  20013, 3707-3709.
92. Tang, T. P.; Volkman, S. K.; Ellman, J. A.
Asymmetric Synthesis of 1,2-Amino Alcohols Using tert-Butanesulfinyl Aldimines and Ketimines
J. Org. Chem.  200166, 8772-8778.
91. Thalji, R.; Ahrendt, K. A.; Bergman, R. G.; Ellman, J. A.
Annulation of Aromatic Imines via Directed C-H Activation with Wilkinson’s Catalyst
J. Am. Chem. Soc.  2001123, 9692-9693.
90. Souers, A. J.; Ellman, J. A.
beta-Turn Mimetic Library Synthesis: Scaffolds and Applications
Tetrahedron  200157, 7431-7448.
89. Souers, A. J.; Owens, T. D.; Oliver, A. G.; Hollander, F. J.; Ellman, J. A.
Synthesis and Crystal Structure of a Unique and Homochiral N,S-Bonded N,N-Bis(-tert-Butanesulfinyl)amidinate Rhodium(I) Complex
Inorg. Chem.  200140, 5299-5301.
88. Dragoli, D. R.; Burdett, M. T.; Ellman, J. A.
Design, Synthesis, and Utility of Support-Bound tert-Butanesulfinamide
J. Am. Chem. Soc.  2001123, 10127-10128.
87. Harris, J. L.; Niles, A.; Burdick, K.; Maffitt, M.; Backes, B. J.; Ellman, J. A.; Kuntz, I.; Haak-Frendscho, M.; Craik, C. S.
Definition of the Extended Substrate Specificity Determinants for beta-Tryptases I and II
J. Biol. Chem.  2001276, 34941-34947.
86. Tan, K. L.; Bergman, R. G.; Ellman, J. A.
Annulation of Alkenyl-Substituted Heterocycles via Rhodium-Catalyzed Intramolecular C-H Activated Coupling Reactions
J. Am. Chem. Soc.  2001123, 2685-2686.
85. Borg, G.; Chino , M.; Ellman, J. A.
Asymmetric Synthesis of Pre-Protected alpha,alpha-Disubstituted Amino Acids from tert-Butanesulfinyl Ketimines
Tetrahedron Lett.  200142, 1433-1436.
84. Owens, T. D.; Hollander, F. J.; Oliver, A. G.; Ellman, J. A.
Synthesis, Utility, and Structure of Novel Bis(sulfinyl)imidoamidine Ligands for Asymmetric Lewis Acid Catalysis
J. Am. Chem. Soc.  2001123, 1539-1540.
83. Szewczyk, J. W.; Zuckermann, R. L.; Bergman, R. G.; Ellman, J. A.
A Mass Spectrometric Labeling Strategy for High-Throughput Reaction Evaluation and Optimization: Exploring C–H Activation
Angew. Chem. Int. Ed.  200140, 216-219.
82. Backes, B. J.; Harris, J. L.; Leonetti, F.; Ellman, J. A.; Craik, C.
Rapid and General Profiling of Protease Specificity by Using Combinatorial Fluorogenic Substrate Libraries
Proc. Natl. Acad. Sci.  200097, 7754-7759.
81. Souers, A. J.; Rosenquist, A.; Jarvie, E. M.; Ladlow, M.; Fenuik, W.; Ellman, J. A.
Optimization of a Somatostatin Mimetic via Constrained Amino Acid and Backbone Incorporation
Bioorg. Med. Chem. Lett.  200010, 2731-2733.

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