Publications

102. Brinner, K. M.; Kim, J. M.; Habashita, H.; Gluzman, I. Y.; Goldberg, D. E.; Ellman, J. A.
Novel and Potent Anti-Malarial Agents
Bioorg. Med. Chem.  2002, 10, 3649-3661.
101. Kochi, T.; Tang, T. P.; Ellman, J. A.
Asymmetric Synthesis of syn- and anti-1,3-Amino Alcohols
J. Am. Chem. Soc.  2002, 124, 6518-6519.
100. Wang, X.; Choe, Y.; Craik, C. S.; Ellman, J. A.
Design and Synthesis of Novel Inhibitors of Gelatinase B
Bioorg. Med. Chem. Lett.  2002, 12, 2201-2204.
99. Tan, K. L.; Bergman, R. G.; Ellman, J. A.
Intermediacy of an N-Heterocyclic Carbene in the Catalytic C-H Activation of Benzimidazole
J. Am. Chem. Soc.  2002, 124, 3202-3203.
98. Kehoe, J. W.; Maly, D. J.; Verdugo, D. E.; Armstrong, J. I.; Cook, B. N.; Ouyang, Y.-B.; Moore, K. L.; Ellman, J. A.; Bertozzi, C. R.
Tyrosylprotein Sulfotransferase Inhibitors Generated by Combinatorial Target-Guided ligand Assembly
Bioorg. Med. Chem. Lett  2002, 12, 329-332.
97. Maly, D. J.; Leonetti, F.; Backes, B. J.; Dauber, D. S.; Harris, J. L.; Craik, C. S.; Ellman, J. A.
Expedient Solid-Phase Synthesis of Fluorogenic Protease Substrates Using the 7-Amino-4-Carbamoylmethylcoumarin (ACC) Fluorophore
J. Org. Chem.  2002, 67, 910-915.
96. Maly, D. J.; Huang, L.; Ellman, J. A.
Combinatorial Strategies for Targeting Protein Families.  Application to the Proteases
ChemBioChem  2002, 3, 16-37.
95. Huang, L.; Lee, A.; Ellman, J. A.
Identification of Potent and Selective Mechanism-Based Inhibitors of the Cysteine Protease Cruzain Using Solid-Phase Parallel Synthesis
J. Med. Chem.  2002, 45, 676-684.
94. Dauber, D. S.; Ziermann, R. Parkin, N.; Maly, D. J.; Mahrus, S.; Harris, J. L.; Ellman, J. A.; Petropoulos, C.; Craik, C. S.
Altered Substrate Specificity of Drug-Resistant Human Immunodeficiency Virus Type 1 Protease
J. Virol.  2002, 76, 1359-1368.
93. Lee. A.; Ellman, J. A.
Parallel Solution-Phase Synthesis of Mechanism-Based Cysteine Protease Inhibitors
Org. Lett.  2001, 3, 3707-3709.
92. Tang, T. P.; Volkman, S. K.; Ellman, J. A.
Asymmetric Synthesis of 1,2-Amino Alcohols Using tert-Butanesulfinyl Aldimines and Ketimines
J. Org. Chem.  2001, 66, 8772-8778.
91. Thalji, R.; Ahrendt, K. A.; Bergman, R. G.; Ellman, J. A.
Annulation of Aromatic Imines via Directed C-H Activation with Wilkinson’s Catalyst
J. Am. Chem. Soc.  2001, 123, 9692-9693.
90. Souers, A. J.; Ellman, J. A.
beta-Turn Mimetic Library Synthesis: Scaffolds and Applications
Tetrahedron  2001, 57, 7431-7448.
89. Souers, A. J.; Owens, T. D.; Oliver, A. G.; Hollander, F. J.; Ellman, J. A.
Synthesis and Crystal Structure of a Unique and Homochiral N,S-Bonded N,N-Bis(-tert-Butanesulfinyl)amidinate Rhodium(I) Complex
Inorg. Chem.  2001, 40, 5299-5301.
88. Dragoli, D. R.; Burdett, M. T.; Ellman, J. A.
Design, Synthesis, and Utility of Support-Bound tert-Butanesulfinamide
J. Am. Chem. Soc.  2001, 123, 10127-10128.
87. Harris, J. L.; Niles, A.; Burdick, K.; Maffitt, M.; Backes, B. J.; Ellman, J. A.; Kuntz, I.; Haak-Frendscho, M.; Craik, C. S.
Definition of the Extended Substrate Specificity Determinants for beta-Tryptases I and II
J. Biol. Chem.  2001, 276, 34941-34947.
86. Tan, K. L.; Bergman, R. G.; Ellman, J. A.
Annulation of Alkenyl-Substituted Heterocycles via Rhodium-Catalyzed Intramolecular C-H Activated Coupling Reactions
J. Am. Chem. Soc.  2001, 123, 2685-2686.
85. Borg, G.; Chino , M.; Ellman, J. A.
Asymmetric Synthesis of Pre-Protected alpha,alpha-Disubstituted Amino Acids from tert-Butanesulfinyl Ketimines
Tetrahedron Lett.  2001, 42, 1433-1436.
84. Owens, T. D.; Hollander, F. J.; Oliver, A. G.; Ellman, J. A.
Synthesis, Utility, and Structure of Novel Bis(sulfinyl)imidoamidine Ligands for Asymmetric Lewis Acid Catalysis
J. Am. Chem. Soc.  2001, 123, 1539-1540.
83. Szewczyk, J. W.; Zuckermann, R. L.; Bergman, R. G.; Ellman, J. A.
A Mass Spectrometric Labeling Strategy for High-Throughput Reaction Evaluation and Optimization: Exploring C–H Activation
Angew. Chem. Int. Ed.  2001, 40, 216-219.
82. Backes, B. J.; Harris, J. L.; Leonetti, F.; Ellman, J. A.; Craik, C.
Rapid and General Profiling of Protease Specificity by Using Combinatorial Fluorogenic Substrate Libraries
Proc. Natl. Acad. Sci.  2000, 97, 7754-7759.
81. Souers, A. J.; Rosenquist, A.; Jarvie, E. M.; Ladlow, M.; Fenuik, W.; Ellman, J. A.
Optimization of a Somatostatin Mimetic via Constrained Amino Acid and Backbone Incorporation
Bioorg. Med. Chem. Lett.  2000, 10, 2731-2733.
80. Lee, A.; Szewczyk, J. W.; Ellman, J. A.
“Combinatorial Libraries for Drug Development” in Stimulating Concepts in Chemistry Vogtle, F.; Stoddart, J. F.; Shibasaki, M. Ed.; Wiley-VCH, Weinheim
  2000, , 65-78.
79. Ellman, J. A.
“Combinatorial Methods to Engineer Small Molecules for Functional Genomics” in Ernst Schering Research Foundation workshop Mulzer, J. and Bohlmann, R. Ed.; Springer
  2000, , 183-204.
78. Bi, X.; Lin, B. Haque, T.; Lee, C. E.; Skillman, A. G.; Kuntz, I. D.; Ellman, J. A.; Lynch, G.
Novel Cathepsin D Inhibitors Block the Formation of Hyperphosphorylated Tau Fragments in Hippocampus
J. Neurochem.  2000, 74,  1469-1477.
77. Maly, D. J.; Choong, I. C.; Ellman, J. A.
Combinatorial Target-Guided Ligand Assembly.  Identification of Potent, Sub-type Selective c-Src Inhibitors
Proc. Natl. Acad. Sci.  2000, 65, 1222-1224.
76. Souers, A. J.; Ellman, J. A.
Asymmetric Synthesis of a C-3 Substituted Pipecolic Acid
J. Org. Chem.  2000, 65, 1222-1224.
75. Backes, B. J.; Harris, J. L.; Leonetti, F.; Craik, C.; Ellman, J. A.
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin
Nat. Biotechnol.  2000, 18, 187-194.
74. Shin, Y.; Winans, K. A.; Backes, B. J.; Kent, S. B. H.; Ellman, J. A.; Bertozzi, C. R.
Fmoc-Based Synthesis of Peptide-Thioesters: Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation
J. Am. Chem. Soc.  1999, 121, 11684-11689.
73. Lee, A.; Huang, L.; Ellman, J. A.
General Solid-phase Method for the Preparation of Mechanism-Based Cysteine Protease Inhibitors
J. Am. Chem. Soc.  1999, 121, 9907-9914.

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