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269. |
Oresic Bender, K.; Ofori, L.; van der Linden, W. A.; Mock, E. D.; Datta, G.; Chowdhury, S.; Li, H.; Segal, E.; Lopez, M. S.; Ellman, J. A.; Figdor, C. G.; Bogyo, M.; Verdoes, M.
Design of a Highly Selective Quenched Activity-Based Probe and Its Application in Dual Color Imaging Studies of Cathepsin S Activity Localization
J. Am. Chem. Soc. 2015, 137, 4771–4777.
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268. |
Jamali, H.; Khan, H. A.; Stringer, J. A.; Chowdhury, S. Ellman, J. A.
Identification of Multiple Structurally-Distinct, Nonpeptidic Small Molecule Inhibitors of Protein Arginine Deiminase 3 Using a Substrate-Based Fragment Method
J. Am. Chem. Soc. 2015, 137, 3616–3621.
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267. |
Otley, K. D.; Ellman, J. A.
An Efficient Method for the Preparation of Styrene Derivatives via Rh(III)-Catalyzed Direct C–H Vinylation
Org. Lett. 2015, 17, 1332–1335 [ACS Select Virtual Issue on C-H Functionalization].
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266. |
Matsushima, Y.; Phillips, E. M.; Bergman, R. G.; Ellman, J. A.
Rh(I)-Catalyzed Cycloisomerization of 1,6-Enynes
Synlett 2015, 26, 1533–1536.
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265. |
Baguley, T. D.; Nairn, A. C.; Lombroso, P. J.; Ellman, J. A.
Synthesis of Benzopentathiepin Analogs and Their Evaluation as Inhibitors of the Phosphatase STEP
Bioorg. Med. Chem. Lett. 2015, 25, 1050-1052.
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264. |
Hummel, J. R.; Ellman, J. A.
Cobalt(III)-Catalyzed Synthesis of Indazoles and Furans by C–H Bond Functionalization/Addition/Cyclization Cascades
J. Am. Chem. Soc. 2015, 137, 490–498.
Write-up in Organic Process Research and Development
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263. |
Otley, K. D.; Ellman, J. A.
A Lewis Acid-Catalyzed Annulation to 2,1-Benzisoxazoles
J. Org. Chem. 2014, 79, 8296–8303.
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262. |
Mesganaw, T.; Ellman, J. A.
Convergent Synthesis of Diverse Tetrahydropyridines via Rh(I)-Catalyzed C–H Functionalization Sequences
Org. Process Res. Dev. 2014, 18, 1097–1104.
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261. |
Mesganaw, T.; Ellman, J. A.
Preparative Synthesis of Highly Substituted Tetrahydropyridines via a Rh(I)-Catalyzed C–H Functionalization Sequence
Org. Process Res. Dev. 2014, 18, 1105–1109.
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260. |
Phelan, J. P.; Patel, E. J.; Ellman, J. A.
Catalytic Enantioselective Addition of Thioacids to Trisubstituted Nitroalkenes
Angew. Chem. Int. Ed. 2014, 53, 11329–11332.
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259. |
Xu, J.; Chatterjee, M.; Baguley, T. D.; Brouillette, J.; Kurup, P.; Ghosh, D.; Kanyo, J.; Zhang, Y.; Seyb, K.; Ononenyi, C.; Foscue, E.;Cuny, G. D.; Glicksman, M. A.; Greengard, P.; Lam, T. T.; Tautz, L.; Nairn, A. C.; Ellman, J. A.; Lombroso, P. A.
Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer’s Disease
PLoS Biol. 2014, 12, e1001923.
In search for Alzheimer’s drug, a major STEP forward
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258. |
Wangweerawong, A.; Bergman, R. G.; Ellman, J. A.
Asymmetric Synthesis of α-Branched Amines via Rh(III)-Catalyzed C–H Bond Functionalization
J. Am. Chem. Soc. 2014, 136, 8520–8523.
Research Highlight in Nature Chemistry
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257. |
Duttwyler, S.; Chen, S.; Lu, C.; Mercado, B. Q.; Bergman, R. G.; Ellman, J. A.
Regio- and Stereoselective 1,2-Dihydropyridine Alkylation/Addition Sequence for the Synthesis of Piperidines with Quaternary Centers
Angew. Chem. Int. Ed. 2014, 53, 3877–3880.
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256. |
Buesking, A. W.; Bacauanu, V.; Cai, I.; Ellman, J. A.
Asymmetric Synthesis of Protected α-Amino Boronic Acid Derivatives with an Air- and Moisture-Stable Cu(II) Catalyst
J. Org. Chem. 2014, 79, 3671–3677.
Write-up in Organic Process Research and Development, Research Highlight in Synfacts
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255. |
Buesking, A. W.; Ellman, J. A.
Convergent, Asymmetric Synthesis of Vicinal Amino Alcohols via Rh-Catalyzed Addition of α-Amido Trifluoroborates to Carbonyls
Chem. Sci. 2014, 5, 1983-1987.
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254. |
Baguley, T. D.; Xu, H.-C.; Chatterjee, M.; Nairn, A. C.; Lombroso, P. J.; Ellman, J. A.
Substrate-Based Fragment Identification for the Development of Selective, Nonpeptidic Inhibitors of Striatal-Enriched Protein Tyrosine Phophatase
J. Med. Chem. 2013, 56, 7636-7650.
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253. |
Xu, H. C.; Chowdhury, S.; Ellman, J. A.
Asymmetric Synthesis of Amines Using tert-Butanesulfinamide
Nat. Protoc. 2013, 8, 2271-2280.
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252. |
Khan, H. A.; Ellman, J. A.
Asymmetric Synthesis of α-Aminophosphonate Esters by the Addition of Dialkyl Phosphites to tert-Butanesulfinyl Imines
Synthesis 2013, 45, 3147–3150.
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251. |
Lian, Y.; Hummel, J. R.; Bergman, R. G.; Ellman, J. A.
Facile Synthesis of Unsymmetrical Acridines and Phenazines by a Rhodium(III)-Catalyzed Amination, Cyclization and Aromatization Cascade
J. Am. Chem. Soc. 2013, 135, 12548-12551.
Research Highlight in Synfacts
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250. |
Lian, Y.; Bergman, R. G.; Lavis, L. D.; Ellman, J. A.
Rhodium(III)-Catalyzed Indazole Synthesis by C-H Bond Functionalization and Cyclative Capture
J. Am. Chem. Soc. 2013, 135, 7122-7125.
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249. |
Brasse, M.; Cámpora, J.; Begman, R. G.; Ellman, J. A.
Mechanistic Study of the Oxidative Coupling of Styrene with 2-Phenylpyridine Derivatives Catalyzed by Cationic Rhodium(III) via C–H Activation
J. Am. Chem. Soc. 2013, 135, 6427-6430.
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248. |
Ischay, M. A.; Takase, M. K.; Bergman, R. G.; Ellman, J. A.
Unstabilized Azomethine Ylides for the Stereoselective synthesis of Substituted Piperidines, Tropanes and Azabicyclo[3.1.0] systems
J. Am. Chem. Soc. 2013, 135, 2478-2481.
Spotlights on Recent JACS Publications
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247. |
Duttwyler, S.; Chen, S.; Takase, M. K.; Wiberg, K. B.; Bergman, R. G.; Ellman, J. A.
Proton Donor Acidity Controls Selectivity in Nonaromatic Nitrogen Heterocycle Synthesis
Science 2013, 339, 678-682.
C&E News Research Highlight, Write-up in Organic Process Research & Development, Research Highlight in Synfacts
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246. |
Martin, R. M.; Bergman, R. G.; Ellman, J. A.
Synthesis of Isoquinuclidines from Highly Substituted Dihydropyridines via the Diels-Alder Reaction
Org. Lett. 2013, 15, 444-447.
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245. |
Lian, Y.; Huber, T.; Hesp, K. D.; Bergman, R. G.; Ellman, J. A.
Rhodium(III)-Catalyzed Alkenyl C-H Bond Functionalization: Convergent Synthesis of Furans and Pyrroles
Angew. Chem. Int. Ed. 2013, 52, 629-633.
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244. |
Jung, H. H.; Buesking, A. W.; Ellman, J. A.
Rh-Catalyzed Addition of Arylboroxines to Cyclic N-(Isopropanesulfinyl)ketimines
J. Org. Chem. 2012, 77, 9593-9600.
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243. |
Lian, Y.; Bergman, R. G.; Ellman, J. A.
Rhodium(III)-Catalyzed Synthesis of Phthalides by Cascade Addition and Cyclization of Benzimidates with Aldehydes
Chem. Sci. 2012, 3, 3088-3092.
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242. |
Verdoes, M.; Edgington, L. E.; Scheeren, F. A.; Leyva, M.; Blum, G.; Weiskopf, K.; Bachmann, M. H.; Ellman, J. A.; Bogyo, M.
A Nonpeptidic Cathepsin S Activity-Based Probe for Noninvasive Optical Imaging of Tumor-Associated Macrophages
Chem. Biol. 2012, 19, 619-628.
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241. |
Kimmel, K. L.; Weaver, J. D.; Lee, M.; Ellman, J. A.
Enantio- and Diastereoselective Addition of Cyclohexyl Meldrum’s Acid to β- and α,β-Disubstituted Nitroalkenes via N-Sulfinyl Urea Catalysis
J. Am. Chem. Soc. 2012, 134, 9058-9061.
Research Highlight in Synfacts
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240. |
Xue, Y.; Chowdhury, S.; Liu, X.; Akiyama, Y.; Ellman, J. A.; Ha, Y.
Conformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S′ Subsites
Biochemistry 2012, 51, 3723-3731.
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