Publications

89. Souers, A. J.; Owens, T. D.; Oliver, A. G.; Hollander, F. J.; Ellman, J. A.
Synthesis and Crystal Structure of a Unique and Homochiral N,S-Bonded N,N-Bis(-tert-Butanesulfinyl)amidinate Rhodium(I) Complex
Inorg. Chem.  2001, 40, 5299-5301.
88. Dragoli, D. R.; Burdett, M. T.; Ellman, J. A.
Design, Synthesis, and Utility of Support-Bound tert-Butanesulfinamide
J. Am. Chem. Soc.  2001, 123, 10127-10128.
87. Harris, J. L.; Niles, A.; Burdick, K.; Maffitt, M.; Backes, B. J.; Ellman, J. A.; Kuntz, I.; Haak-Frendscho, M.; Craik, C. S.
Definition of the Extended Substrate Specificity Determinants for beta-Tryptases I and II
J. Biol. Chem.  2001, 276, 34941-34947.
86. Tan, K. L.; Bergman, R. G.; Ellman, J. A.
Annulation of Alkenyl-Substituted Heterocycles via Rhodium-Catalyzed Intramolecular C-H Activated Coupling Reactions
J. Am. Chem. Soc.  2001, 123, 2685-2686.
85. Borg, G.; Chino , M.; Ellman, J. A.
Asymmetric Synthesis of Pre-Protected alpha,alpha-Disubstituted Amino Acids from tert-Butanesulfinyl Ketimines
Tetrahedron Lett.  2001, 42, 1433-1436.
84. Owens, T. D.; Hollander, F. J.; Oliver, A. G.; Ellman, J. A.
Synthesis, Utility, and Structure of Novel Bis(sulfinyl)imidoamidine Ligands for Asymmetric Lewis Acid Catalysis
J. Am. Chem. Soc.  2001, 123, 1539-1540.
83. Szewczyk, J. W.; Zuckermann, R. L.; Bergman, R. G.; Ellman, J. A.
A Mass Spectrometric Labeling Strategy for High-Throughput Reaction Evaluation and Optimization: Exploring C–H Activation
Angew. Chem. Int. Ed.  2001, 40, 216-219.
82. Backes, B. J.; Harris, J. L.; Leonetti, F.; Ellman, J. A.; Craik, C.
Rapid and General Profiling of Protease Specificity by Using Combinatorial Fluorogenic Substrate Libraries
Proc. Natl. Acad. Sci.  2000, 97, 7754-7759.
81. Souers, A. J.; Rosenquist, A.; Jarvie, E. M.; Ladlow, M.; Fenuik, W.; Ellman, J. A.
Optimization of a Somatostatin Mimetic via Constrained Amino Acid and Backbone Incorporation
Bioorg. Med. Chem. Lett.  2000, 10, 2731-2733.
80. Lee, A.; Szewczyk, J. W.; Ellman, J. A.
“Combinatorial Libraries for Drug Development” in Stimulating Concepts in Chemistry Vogtle, F.; Stoddart, J. F.; Shibasaki, M. Ed.; Wiley-VCH, Weinheim
  2000, , 65-78.
79. Ellman, J. A.
“Combinatorial Methods to Engineer Small Molecules for Functional Genomics” in Ernst Schering Research Foundation workshop Mulzer, J. and Bohlmann, R. Ed.; Springer
  2000, , 183-204.
78. Bi, X.; Lin, B. Haque, T.; Lee, C. E.; Skillman, A. G.; Kuntz, I. D.; Ellman, J. A.; Lynch, G.
Novel Cathepsin D Inhibitors Block the Formation of Hyperphosphorylated Tau Fragments in Hippocampus
J. Neurochem.  2000, 74,  1469-1477.
77. Maly, D. J.; Choong, I. C.; Ellman, J. A.
Combinatorial Target-Guided Ligand Assembly.  Identification of Potent, Sub-type Selective c-Src Inhibitors
Proc. Natl. Acad. Sci.  2000, 65, 1222-1224.
76. Souers, A. J.; Ellman, J. A.
Asymmetric Synthesis of a C-3 Substituted Pipecolic Acid
J. Org. Chem.  2000, 65, 1222-1224.
75. Backes, B. J.; Harris, J. L.; Leonetti, F.; Craik, C.; Ellman, J. A.
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin
Nat. Biotechnol.  2000, 18, 187-194.
74. Shin, Y.; Winans, K. A.; Backes, B. J.; Kent, S. B. H.; Ellman, J. A.; Bertozzi, C. R.
Fmoc-Based Synthesis of Peptide-Thioesters: Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation
J. Am. Chem. Soc.  1999, 121, 11684-11689.
73. Lee, A.; Huang, L.; Ellman, J. A.
General Solid-phase Method for the Preparation of Mechanism-Based Cysteine Protease Inhibitors
J. Am. Chem. Soc.  1999, 121, 9907-9914.
72. Dragoli, D. R.; Ellman, J. A.
Parallel Solid-Phase Synthesis of Prostaglandin E Analogs
J. Comb. Chem.  1999, 1, 534-539.
71. Huang, L.; Lee, A.; Ellman, J. A.
Targeted Libraries
Proceedings of the 16th American Peptide Symposium  2000, , 161-163.
70. Haskell-Leuvano, C.; Souers, A. J.; Rosenquist, A., Ellman, J. A.; Cone, R. D.
Identification of Agonists at the Human Melanocortin Receptor MC1R By the Evaluation of a Library of Small Molecules Based upon the b-Turn
J. Med. Chem.  1999, 42, 4380-4387.
69. Ramdas, L.; Bunin, B. A.; Plunkett, M. J.; Sun, G.; Ellman, J. A.; Gallick, G.; Budde, R. J. A.
Benzodiazepine Compounds as Inhibitors of the Src Protein Tyrosine Kinase: Screening of a Combinatorial Library of 1,4-Benzodiazepines
Archives of Biochem. And Biophys.  1999, 368, 394-400.
68. Choong, I. C.; Ellman, J. A.
Expedient Synthesis of Alkoxylamines Using tert-Butyl Oxaziridine: The First Direct Amination of Alcohols
J. Org. Chem.  1999, 64, 6528-6529.
67. Borg, G.; Cogan, D. A.; Ellman, J. A.
One-Pot Asymmetric Reductive Amination of Ketones to Prepare tert-Butanesulfinyl Protected Amines
Tetrahedron Lett.  1999, 40, 6709-6712.
66. Backes, B. J.; Dragoli, D. R.; Ellman, J. A.
Chiral N-Acyl-tert-Butanesulfinamides:  The “Safety-Catch” Principle Applied to Diastereoselective Enolate Alkylations
J. Org. Chem.  1999, 64, 5472-5478.
65. Xu, R.; Greiveldinger, G.; Marenus, L. E.; Cooper, A. G.; Ellman, J. A.
Combinatorial Library Approach to the Development of Synthetic Receptors Targeting Vancomycin Resistant Bacteria
J. Am. Chem. Soc.  1999, 55, 8883-8904.
64. Cogan, D. A.; Liu, G.; Ellman, J. A.
Asymmetric Synthesis of Chiral Amines by Highly Diastereoselective 1,2-Additions of Organometallic Reagents to N-tert-Butanesulfinyl Imines
Tetrahedron  1999, 55, 8883-8904.
63. Haque, T. S.; Skillman, A. G.; Lee, C. E.; Habashita, H.; Gluzman, I. Y.; Ewing, T. J. A.; Goldberg, D. E.; Kuntz, I. D.; Ellman, J. A.
Single Digit Nanomolar, Low Molecular Weight Non-Peptide Inhibitors of Malarial Aspartyl Protease Plasmepsin II
J. Med. Chem.  1999, 42, 1428-1440.
62. Backes, B. J.; Ellman, J. A.
An Alkanesulfonamide “Safety-Catch” Linker for Solid-Phase Synthesis
J. Org. Chem.  1999, 64, 2322-2330.
61. Souers, A. J.; Schürer, Kwack, H.; Virgilio, A. A.; Ellman, J. A.
Preparation of Enantioenriched alpha-Bromo Acids with Diverse Side Chain Functionality
Synthesis  1999, , 583-585.
60. Liu, G.; Cogan, D. A.; Owens, T. D.; Tang, T. P.; Ellman, J. A.
The Synthesis of Enantiomerically Pure N-tert-Butanesulfinyl Imines (tert-Butanesulfinimines) by the Direct Condensation of tert-Butanesulfinamide with Aldehydes and Ketones
J. Org. Chem.  1999, 64, 1278-1284.

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