Publications

80. Lee, A.; Szewczyk, J. W.; Ellman, J. A.
“Combinatorial Libraries for Drug Development” in Stimulating Concepts in Chemistry Vogtle, F.; Stoddart, J. F.; Shibasaki, M. Ed.; Wiley-VCH, Weinheim
  2000, , 65-78.
79. Ellman, J. A.
“Combinatorial Methods to Engineer Small Molecules for Functional Genomics” in Ernst Schering Research Foundation workshop Mulzer, J. and Bohlmann, R. Ed.; Springer
  2000, , 183-204.
78. Bi, X.; Lin, B. Haque, T.; Lee, C. E.; Skillman, A. G.; Kuntz, I. D.; Ellman, J. A.; Lynch, G.
Novel Cathepsin D Inhibitors Block the Formation of Hyperphosphorylated Tau Fragments in Hippocampus
J. Neurochem.  2000, 74,  1469-1477.
77. Maly, D. J.; Choong, I. C.; Ellman, J. A.
Combinatorial Target-Guided Ligand Assembly.  Identification of Potent, Sub-type Selective c-Src Inhibitors
Proc. Natl. Acad. Sci.  2000, 65, 1222-1224.
76. Souers, A. J.; Ellman, J. A.
Asymmetric Synthesis of a C-3 Substituted Pipecolic Acid
J. Org. Chem.  2000, 65, 1222-1224.
75. Backes, B. J.; Harris, J. L.; Leonetti, F.; Craik, C.; Ellman, J. A.
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin
Nat. Biotechnol.  2000, 18, 187-194.
74. Shin, Y.; Winans, K. A.; Backes, B. J.; Kent, S. B. H.; Ellman, J. A.; Bertozzi, C. R.
Fmoc-Based Synthesis of Peptide-Thioesters: Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation
J. Am. Chem. Soc.  1999, 121, 11684-11689.
73. Lee, A.; Huang, L.; Ellman, J. A.
General Solid-phase Method for the Preparation of Mechanism-Based Cysteine Protease Inhibitors
J. Am. Chem. Soc.  1999, 121, 9907-9914.
72. Dragoli, D. R.; Ellman, J. A.
Parallel Solid-Phase Synthesis of Prostaglandin E Analogs
J. Comb. Chem.  1999, 1, 534-539.
71. Huang, L.; Lee, A.; Ellman, J. A.
Targeted Libraries
Proceedings of the 16th American Peptide Symposium  2000, , 161-163.
70. Haskell-Leuvano, C.; Souers, A. J.; Rosenquist, A., Ellman, J. A.; Cone, R. D.
Identification of Agonists at the Human Melanocortin Receptor MC1R By the Evaluation of a Library of Small Molecules Based upon the b-Turn
J. Med. Chem.  1999, 42, 4380-4387.
69. Ramdas, L.; Bunin, B. A.; Plunkett, M. J.; Sun, G.; Ellman, J. A.; Gallick, G.; Budde, R. J. A.
Benzodiazepine Compounds as Inhibitors of the Src Protein Tyrosine Kinase: Screening of a Combinatorial Library of 1,4-Benzodiazepines
Archives of Biochem. And Biophys.  1999, 368, 394-400.
68. Choong, I. C.; Ellman, J. A.
Expedient Synthesis of Alkoxylamines Using tert-Butyl Oxaziridine: The First Direct Amination of Alcohols
J. Org. Chem.  1999, 64, 6528-6529.
67. Borg, G.; Cogan, D. A.; Ellman, J. A.
One-Pot Asymmetric Reductive Amination of Ketones to Prepare tert-Butanesulfinyl Protected Amines
Tetrahedron Lett.  1999, 40, 6709-6712.
66. Backes, B. J.; Dragoli, D. R.; Ellman, J. A.
Chiral N-Acyl-tert-Butanesulfinamides:  The “Safety-Catch” Principle Applied to Diastereoselective Enolate Alkylations
J. Org. Chem.  1999, 64, 5472-5478.
65. Xu, R.; Greiveldinger, G.; Marenus, L. E.; Cooper, A. G.; Ellman, J. A.
Combinatorial Library Approach to the Development of Synthetic Receptors Targeting Vancomycin Resistant Bacteria
J. Am. Chem. Soc.  1999, 55, 8883-8904.
64. Cogan, D. A.; Liu, G.; Ellman, J. A.
Asymmetric Synthesis of Chiral Amines by Highly Diastereoselective 1,2-Additions of Organometallic Reagents to N-tert-Butanesulfinyl Imines
Tetrahedron  1999, 55, 8883-8904.
63. Haque, T. S.; Skillman, A. G.; Lee, C. E.; Habashita, H.; Gluzman, I. Y.; Ewing, T. J. A.; Goldberg, D. E.; Kuntz, I. D.; Ellman, J. A.
Single Digit Nanomolar, Low Molecular Weight Non-Peptide Inhibitors of Malarial Aspartyl Protease Plasmepsin II
J. Med. Chem.  1999, 42, 1428-1440.
62. Backes, B. J.; Ellman, J. A.
An Alkanesulfonamide “Safety-Catch” Linker for Solid-Phase Synthesis
J. Org. Chem.  1999, 64, 2322-2330.
61. Souers, A. J.; Schürer, Kwack, H.; Virgilio, A. A.; Ellman, J. A.
Preparation of Enantioenriched alpha-Bromo Acids with Diverse Side Chain Functionality
Synthesis  1999, , 583-585.
60. Liu, G.; Cogan, D. A.; Owens, T. D.; Tang, T. P.; Ellman, J. A.
The Synthesis of Enantiomerically Pure N-tert-Butanesulfinyl Imines (tert-Butanesulfinimines) by the Direct Condensation of tert-Butanesulfinamide with Aldehydes and Ketones
J. Org. Chem.  1999, 64, 1278-1284.
59. Souers, A. J.; Virgilio, A. A.; Rosenquist, A.; Fenuik, W. Ellman, J. A.
Identification of a Potent Heterocyclic Ligand to Somatostatin Receptor Sub-Type 5 by the Synthesis and Screening of beta-Turn Mimetic Libraries
J. Am. Chem. Soc.  1999, 121, 1817-1825.
58. Cogan, D. A.; Ellman, J. A.
The Asymmetric Synthesis of alpha,alpha-Dibranched Amines by the Trimethylaluminum Mediated 1,2-Addition of Organolithiums to tert-Butanesulfinyl Ketimines
J. Am. Chem. Soc.  1999, 121, 268-269.
57. Tang, T. P.; Ellman, J. A.
The tert-Butanesulfinyl Group: An Ideal Chiral Directing Group and Boc-Surrogate for Asymmetric  beta-Amino Acid Synthesis and Applications
J. Org. Chem.  1999, 64, 12-13.
56. Kim, K.; Volkman, S. K.; Ellman, J. A.
Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones
J. Braz. Chem. Soc.  1998, 9, 375-379.
55. Lee, C. E.; Kick, E. K.; Ellman, J. A.
General Solid-Phase Synthesis Approach to Prepare Mechanism-Based Aspartyl Protease Inhibitor Libraries.  Identification of Potent Cathepsin D Inhibitors
J. Am. Chem. Soc.  1998, 120, 9735-9748.
54. Souers, A. J.; Virgilio, A. A.; Schürer, S. S.; Ellman, J. A.; Vanderslice, P.; Kogan, T. P.
Novel Inhibitors of alpha-4-beta-1 Integrin Receptor Interactions Through Library Synthesis and Screening
Bioorg. Med. Chem. Lett.  1998, 8, 2297-2303.
53. Cogan, D. A.; Liu, G.; Kim, K.; Backes, B. A.; Ellman, J. A.
Catalytic Asymmetric Oxidation of tert-Butyl Disulfide.  Synthesis of tert-Butanesulfinamides, tert-Butyl Sulfoxide, and tert-Butanesulfinimines
J. Am. Chem. Soc.  1998, 120, 8011-8019.
52. Ellman, J. A.; Gallop, M. A.
Combinatorial Chemistry
Curr. Opin. Chem. Biol.  1998, 2, 317-319.
51. Thompson, L. A.; Moore, F. L.; Moon, Y.-C.; Ellman, J. A.
Solid-Phase Synthesis of Diverse E- F- Series Prostaglandins
J. Org. Chem.  1998, 63, 2066-2067.

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