Publications

55. Lee, C. E.; Kick, E. K.; Ellman, J. A.
General Solid-Phase Synthesis Approach to Prepare Mechanism-Based Aspartyl Protease Inhibitor Libraries.  Identification of Potent Cathepsin D Inhibitors
J. Am. Chem. Soc.  1998, 120, 9735-9748.
54. Souers, A. J.; Virgilio, A. A.; Schürer, S. S.; Ellman, J. A.; Vanderslice, P.; Kogan, T. P.
Novel Inhibitors of alpha-4-beta-1 Integrin Receptor Interactions Through Library Synthesis and Screening
Bioorg. Med. Chem. Lett.  1998, 8, 2297-2303.
53. Cogan, D. A.; Liu, G.; Kim, K.; Backes, B. A.; Ellman, J. A.
Catalytic Asymmetric Oxidation of tert-Butyl Disulfide.  Synthesis of tert-Butanesulfinamides, tert-Butyl Sulfoxide, and tert-Butanesulfinimines
J. Am. Chem. Soc.  1998, 120, 8011-8019.
52. Ellman, J. A.; Gallop, M. A.
Combinatorial Chemistry
Curr. Opin. Chem. Biol.  1998, 2, 317-319.
51. Thompson, L. A.; Moore, F. L.; Moon, Y.-C.; Ellman, J. A.
Solid-Phase Synthesis of Diverse E- F- Series Prostaglandins
J. Org. Chem.  1998, 63, 2066-2067.
50. Woolard, F. X.; Paetsch, J.; Ellman, J. A.
A Silicon Linker for the Direct Loading of Aromatic Compounds onto Solid Supports.  Traceless Synthesis of Pyridyl-Based Tricyclics
J. Org. Chem.  1997, 62, 6102-6103.
49. Liu, G.; Cogan, D. A.; Ellman, J. A
Catalytic Asymmetric Synthesis of tert-Butanesulfinamide.  Application to the Asymmetric Synthesis of Amines
J. Am. Chem. Soc.  1997, 119, 9913-9914.
48. Backes, B. A.; Ellman, J. A.
Solid Support Linker Strategies
Curr. Opin. Chem. Biol.  1997, 1, 86-94.
47. Kick, E. K.; Roe, D. C.; Skillman, A. G.; Liu, G.; Ewing, T. J. A.; Sun, Y.; Kuntz, I. D.; Ellman, J. A.
Structure-Based Design and Combinatorial Chemistry Yield Low Nanomolar Inhibitors of Cathepsin D
Chem. Biol.  1997, 4, 297-309.
46. Virgilio, A. A.; Bray, A. A.; Zhang, W.; Ellman, J. A.
Synthesis and Evaluation of a Library of Peptidomimetics Based upon the beta-Turn
Tetrahedron  1997, 53, 6635-6644.
45. Plunkett, M. J.; Ellman, J. A.
Germanium and Silicon Linking Strategies for Traceless Solid-Phase Synthesis
J. Org. Chem.  1997, 62, 2885-2893.
44. Ellman, J. Stoddard, B.; Wells, J.
Combinatorial Thinking in Chemistry and Biology
Proc. Natl. Acad. Sci., USA  1997, 94, 2779-2782.
43. Evans, D. A.; Barrow, J. C.; Watson, P. S.; Ratz, A. M.; Dinsmore, C. J.; Evrard, D. A.; DeVries, K.; Ellman, J. A.; Rychnovsky, S. D.; Lacour, J
Synthesis and Conformational Properties of the M(4-6)(5-7) Bicyclic Tetrapeptide Common to the Vancomycin Antibiotics
J. Am. Chem. Soc.  1997, 119, 3419-3420.
42. Boojamra, C. G.; Burow, K. M.; Thompson, L. A.; Ellman, J. A.
The Solid-Phase Synthesis of 1,4-Benzodiazepine-2,5-diones.  Library Preparation and Demonstration of Synthesis Generality
J. Org. Chem.  1997, 62, 1240-1257.
41. Plunkett, M. J.; Ellman, J. A.
Combinatorial Chemistry and New Drugs
Sci. Am.  1997, 276, 68-73.
40. Plunkett, M. J.; Ellman, J. A.
“Combinatorial Chemistry” in McGraw-Hill Yearbook of Science & Technology, Parker, S. P., Ed.; McGraw-Hill Book Co.: New York, New York,
  1997, , 95-99.
39. Bunin, B. A.; Plunkett, M. J.; Bray, A. M.; Ellman, J. A.
The Synthesis of a 1680 Compound 1,4-Benzodiazepine Library
New J. Chem.  1997, 21, 125.
38. Choong, I. C.; Ellman, J. A.
Solid-Phase Synthesis: Application of Combinatorial Libraries
in Annu. Rep. Med. Chem.  1996, 31, 309-318.
37. Stevens, S. Y.; Bunin, B. A.; Plunkett, M. J.; Swanson, P. C.; Ellman, J. A.; Glick, G. D.
Non-Nucleic Acid Inhibitors of Protein-DNA Interactions Identified through Combinatorial Chemistry
J. Am. Chem. Soc.  1996, 118, 10650-10651.
36. Virgilio, A. A.; Schürer, S.; Ellman, J. A
Expedient Synthesis of beta-Turn Mimetics Incorporating the i + 1, i + 2, and i + 3 Sidechains
Tetrahedron Lett.  1996, 37, 6961-6964.
35. Backes, B. J.; Virgilio, A. A.; Ellman, J. A
Activation Method to Prepare a Highly Reactive Acylsulfonamide “Safety-Catch” Linker for Solid-Phase Synthesis
J. Am. Chem. Soc.  1996, 118, 3055-3057.
34. Koh, J. S.; Ellman, J. A
Palladium-Mediated Three-Component Coupling Strategy for the Solid-Phase Synthesis of Tropane Derivatives
J. Org. Chem.  1996, 61, 4494-4495.
33. Virgilio, A. A.; Ellman, J. A.
“Conformationally Restricted Peptide and Peptidomimetic Libraries” in Combinatorial Chemistry and Molecular Diversity in Drug Discovery; Gordon, E. M. and Kerwin, J. F. Ed.; John Wiley & Sons, Inc.: New York, New York,
  1998, ,  133-151.
32. Ellman, J. A
The Solid-Phase Synthesis of Complex Small Molecules
Chimia  1996, 50, 260-261.
31. Ellman, J. A
Design, Synthesis, and Evaluation of Small-Molecule Libraries
Acc. Chem. Res.  1996, 29, 132-143.
30. Thompson, L. A.; Ellman, J. A.
Synthesis and Applications of Small Molecule Libraries
Chem. Rev.  1996, 96, 555-600.
29. Bunin, B. A.; Plunkett, M. J.; Ellman, J. A.
Synthesis and Evaluation of 1,4-Benzodiazepine Libraries
Methods Enzymol.  1996, 267,  448-467.
28. Liu, G.; Ellman, J. A.
A General Solid-Phase Synthesis Strategy for the Preparation of 2-Pyrrolidinemethanol Ligands
J. Org. Chem.  1995, 60, 7712–7713.
27. Plunkett, M. J.; Ellman, J. A
Silicon-Based Linkage Strategy for Traceless Solid-Phase Synthesis
J. Org. Chem.  1995, 60, 6006-6007.
26. Boojamra, C G.; Burow, K. J.; Ellman, J. A
A General and Straightforward Method for the Solid-Phase Synthesis of 1,4-Benzodiazepine-2,5-diones
J. Org. Chem.  1995, 60, 5742-5743.

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